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  • Cushing's disease is a condition in which the adrenal glands over-produce certain hormones. It may be caused by a pituitary gland tumor, an adrenal tumor, or prolonged corticosteroid use. Clinical signs include poor haircoat, pot-bellied appearance, increased drinking, and increased urination. Medical and surgical treatment options are discussed. Prognosis varies but is improved with intervention.

  • Darbepoetin alfa is prescribed off label to treat low red blood cell levels (anemia) caused by progressing kidney disease in dogs and cats. It is administered by injections under the skin.

  • If a tooth is unerupted, it is at risk of forming a destructive dentigerous (odontogenic) cyst in the bone. Although unerupted or broken teeth can be painful, dogs rarely show obvious signs of pain. Dentigerous cysts, including and the original tooth must be removed carefully as to avoid compromising the bone, which can easily fracture during the extraction. Dentigerous cysts are preventable if unerupted teeth are addressed early in life.

  • Desoxycorticosterone pivalate (DOCP) (brand name Percorten-V®, Zycortal®) is a steroid hormone replacement therapy used to treat primary hypoadrenocorticism (Addison’s disease) in dogs. Extra-label (off-label) lower dosages of DOCP (i.e., lower dose, longer dosing interval, or both) can be used to control the balance of blood electrolyte levels. DOCP has also been used extra-label to treat hypoadrenocorticism in cats.

  • Dexamethasone ophthalmic is a topical steroid medication used to treat inflammatory eye conditions in cats, dogs, rabbits, avian species, and other animals. Dexamethasone ophthalmic may be used alone or in combination with an antimicrobial. Dexamethasone ophthalmic comes in ointment and liquid drop form. Avoid use in animals with corneal ulcerations or corneal infections.

  • Dexamethasone Otic is a steroid medication used in pets to treat topical inflammation of the ears, often with other medications such as antibiotics. It comes as a liquid solution that is prescribed for topical use within a pet’s ear canal. There are no veterinary brands of dexamethasone otic.

  • Dextromethorphan + Guaifenesin is given by mouth as a tablet and is used off label to reduce cough in dogs and cats or to treat compulsive behavior. Side effects are uncommon, but serious adverse reactions associated with this drug may occur without warning. Contact your veterinarian if you notice anything out of the ordinary.

  • Diabetes mellitus results from an inadequate production of insulin from the pancreas. The primary treatment is replacement by insulin injections. The body's response to the injections needs to be regularly monitored using an at-home glucometer or continuous glucose monitoring system. Insulin must be stored and reconstituted carefully to ensure dosing is accurate. Giving subcutaneous injections of insulin can seem daunting at first, but by following the directions in this handout, it will quickly become second nature to both you and your pet.

  • New medications can help regulate blood glucose levels in cats, including once-daily oral medications bexagliflozin (Bexacat) and velagliflozin (Senvelgo). Cats in the initial stages of DM may benefit most from oral diabetes treatments. This article discusses how these medications work, potential risks, and monitoring required.

  • Diabetes mellitus is an inability to regulate blood glucose caused by a loss of insulin production (Type I) or inadequate insulin supply or resistance (Type II). In cats, diabetes mellitus is most often type II. This type of diabetes usually results from obesity, creating insulin resistance. Cats with type II may be treated with oral medication, but some cats may ultimately require insulin injections. Diet is also important. This article discusses various treatments and monitoring regimens.